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Elevated liver enzymes do not directly correlate with toxicity but therapy should be stopped and doses of methotrexate reduced if transaminases are elevated to 2 times the upper limit of normal.

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basic pharmacology methotrexate is a folate antimetabolite that inhibits di- phenylbutazone-type drugs hydrofolate reductase and other folate-dependent en- the phenylbutazone-type drugs include phenylbuta- zymes in cells.

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