The weird part about taking allopurinol is that in the beginning ,it may increase the number of gout attacks cause it can take up to several weeks for this drug to take effect.
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to reduce the possibility of flare-up of acute gouty attacks, it is recommended that the patient start with a low dose of zyloprim allopurinol 100 mg daily and increase at weekly intervals by 100 mg until a serum uric acid level of 6 mg dl or less is attained but without exceeding the maximal recommended dosage.